The vision of the National Laboratory for Health Security is to provide the scientific basis for data and analysis-based decision making in the fields of health, disease prevention and ecosystems in Hungary. The three areas are closely intertwined and new synergies will be created through innovative surveillance systems, big data methods and mathematical modelling. The Laboratory will bring together and coordinate research teams that have been working in isolation in the country, fostering networking and creating a collaborative research community with high visibility on the international scene.