Page 39 - Roadmap

7.3. HEALTH AND FOOD SCIENCES

BIOIMAGING RESEARCH INFRASTRUCTURE GROUP
EURO-BIOIMAGING CONSORTIUM

Presentation of the RI group
Advanced Light Microscopy and medical imaging play an increasingly important role in biomedical basic and applied
research and in diagnostics, which is clearly confirmed by the two recent Nobel Prizes in this field (2014: super-resolved
fluorescence microscopy, 2017: cryo-electron microscopy). Under the governance of European light microscopy and
medical imaging microscopy laboratories, the Euro-BioImaging (EuBI) ESFRI consortium was formed in December
2010 (www.eurobioimaging.eu) and will operate as an ERIC. The aim of the consortium is to connect European mi-
croscopy and medical imaging service provider laboratories into a network. The Hungarian BioImaging Network was
established in 2009 with 26 members. Several members of the network (University of Debrecen, Semmelweis University,
HAS Biological Research Centre, Femtonics Ltd.) have partnered in a joint EuBI Node project proposal.
The non-exhaustive list of technologies available in the infrastructures: super-resolution systems capable of single-
molecule detection and approximation (stimulated emission depletion, STED, two-photon STED; photoactivated lo-
calization microscopy, PALM; stochastic optical reconstruction microscopy, STORM; structured illumination
microscopy, SIM), optical tweezers, in vivo functional microscopy (e.g. multiphoton microscopy, 2D and 3D, fast two
and three-photon scanning laser microscopy; Förster resonance energy transfer, FRET-microscopy; fluorescence lifetime
imaging microscopy, FLIM, rescueSTED-FLIM; fluorescence [cross]correlation spectroscopy, F[C]CS; differential
polarization laser scanning microscopy, DP-LSM; Rescan Confocal Microscopy [RCM] with polarization imaging at-
tachment; total internal reflection fluorescence, TIRF), stimulated Raman spectroscopy (SRS), high throughput mi-
croscopy, machine learning algorithms, automated image analysis, laser dissection and analysis of unique cells, functional
medical imaging equipment (e.g. CT, PET/CT, MRI, SPECT, fMRI, NEXSTIM), pet imaging equipment for pre-
clinical, translational research (e.g. mini-PET, nano-PET/CT, PET/MRI, fMRI, micro-CT, bioluminescence imager).
Application areas of the infrastructure in biological and biomedical basic and applied research: brain research, devel-
opment of surgical diagnostic and therapeutic devices, drug design, nano-biotechnology, structural biology, membrane
biology, cell biology, developmental biology, bioinspired smart materials. Group members engage in methodology and
device development and manufacturing. The partners are cooperating in a number of running projects. The infrastruc-
tures are also available for domestic and foreign researchers.and foreign researchers.rs.

National coordinator of the RI group: Background information
University of Debrecen The Hungarian BioImaging Network operates as a distributed re-
search infrastructure. The diversity of the methods requires speciali-
Contact: György Vámosi sation. 26 university and research institution laboratories form part
Email: vamosig@med.unideb.hu of the network, and several other labs have indicated their intention
Website: http://biophys.med.unideb.hu/en/Molecular%20Cell%20Analy- to join. The partners have world-class instrument parks, developed
sis%20Core%20Facility in a coordinated manner from GINOP instrument development
http://bioimaging.unideb.hu/List_of_Facilities funding. The members of the network have partnered in several joint
GINOP project proposals in which BioImaging plays a decisive role.
Partners: University of Debrecen - multiple locations; HAS Biological Re- Several members of the network participated in a joint Euro-
search Centre - multiple locations; University of Pécs - Szentágothai Rese- Bioimaging Node project proposal in 2014, which was endorsed by
arch Centre; UP Medical School, Clinical Centre; Semmelweis University the professional jury and ratified by the EuBI Interim Board.
– multiple locations; University of Kaposvár; HAS Institute for Nuclear
Research; HAS Institute of Experimental Medicine; Femtonics Ltd.; Eötvös Aim of the RI group
Loránd University; HAS Research Centre for Natural Sciences; University The current goal is to make the Euro-Bioimaging Node operational,
of Szeged which will satisfy the needs of domestic and European researchers,
connecting them to the global research community. Due to the
ESFRI connection: Euro-BioImaging rapid development of imaging technology, there is a continuous de-
Status of the RI group: under implementation mand for developing the infrastructures. This development activity
is largely carried out by the members of the RI group.

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