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8.3. HEALTH AND FOOD SCIENCES
NATIONAL HEART PROGRAMME Research and innovation in the diagnosis and therapy of
ischemic heart disease and heart failure
Semmelweis University
Project code: Project description:
NVKP_16-1-2016-0017 The project aims to research and develop innovative diagnostic and therapeutic met-
hods, services and products for the reduction of morbidity and mortality of ischemic
Project leader institution: heart disease and heart failure by establishing interdisciplinary, closely integrated trans-
Semmelweis University lational RDI platforms (from basic research to epidemiology).
Project leader: Establishment of cardiology R&D service provider core facilities:
Béla Merkely 1. molecular and small animal imaging core laboratory; 2. cardiovascular imaging core
laboratory; 3. experimental small animal core laboratory; 4. experimental large animal
Project leader’s contacts: core laboratory; 5. bioinformatics core laboratory; 6. cell technology core-laboratory;
se.kardiologiai.kp.titkarsag@gmail.com 7. histology core laboratory.
Project partners: The laboratories will offer a cost-efficient and world class infrastructure for the imple-
SE; Mediso Kft.; mentation of the programme, and will provide long-term service.
Pharmahungary 2000 Kft.; The main task groups of translational research projects, and product and service deve-
Twinmed Kft.; lopment projects:
Neumann Projekt Kft.
a) Identification and validation of the gene and protein expression pattern of patients’
Amount of funding: myocardial tissue; the creation of a blood-derived exosome isolation platform; myo-
HUF 3,299,426,997 cardial cell-derived extracellular vesicles biomarkers with multiomic methods.
b) Development of minimally invasive catheter technologies and cardioprotective the-
RI type: Distributed rapies with modern procedures for effective blood flow restoration, and the deve-
lopment of a new catheter prototype for this.
Website: http://vszek.semmel- c) Improvement of the success rate of heart failure resynchronization device therapies
weis.hu/nemzeti-szivprogram and development of a new guideline.
d) Development of automated image analysis and structured reporting software, and
exploration of new image information (radiomics) that fit with the national e-Health
programme.
e) Development of high-res PET/CT for the examination of animal models.
f) Examination of the epidemiological background of cardiovascular diseases (ge-
notype, phenotype and environment interaction),
Goal: world market sale of products and services developed in the project, and their
further development with industrial partners.
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